Sunday, March 27, 2022

How Billionaires and Capitalism Save Billions of Lives - Including Yours

The Shortest Version

Stuart K. Hayashi




Table of Contents

INTRODUCTION
PART ONE: PROFILES OF LIFESAVING FOR-PROFIT ENTERPRISES
* Creativity in the Age of COVID – Makers of the COVID Vaccine
* Patrick and Paclitaxel – Patrick Soon-Shiong and His Cancer Drug
* Index to Additional Case Studies of Lifesaving For-Profit Initiatives
*Fritz and His Fertilizer – Fritz Haber, Carl Bosch, and Synthetic Nitrogen Fertilizer

PART TWO: HOW, CUMULATIVELY, BILLIONAIRES SAVE BILLIONS OF LIVES
* Value Added to Natural Resources
* Natural Fact One (of Two): Resource Substitution
* Natural Fact Two (of Two): Greater Utility From Fewer and Smaller Inputs
* The Carrying Capacity of Land
* Improved Productivity Helps People on the Lower Income Distribution
* Goods That Have Not Decreased in Real Price
* The Poor Get Richer
* What Capitalism Can Do for the Climate
* Capitalism Vs. Hunter-Gatherer Life Vs. Socialism
* Capitalism Vs. Taxpayer Funding for Basic Research and R-and-D
CONCLUSION



INTRODUCTION | ^ 

 America’s billionaires are rich in their finances and poor in reputation. They have not been getting good press lately.

For much of the past few decades, the common attitude in America was that it is morally permissible to become a billionaire as long as one “gives back” in the form of philanthropy. That was the attitude formalized in The Gospel of Wealth penned by the richest man of its day, Andrew Carnegie. But over the past several years, the debate has shifted to whether it should be legal for any entrepreneur to become a billionaire at all.

Heralding this change was a January 2019 interview that left-wing writer Ta-Nehisi Coates conducted with then-freshman U.S. Sen. Alexandria Ocasio-Cortez. “Do we live in a moral world [if it is one] that allows for billionaires?” Coates asked her. “Is that a moral outcome?”

“No, it is not,” she replied. For this, she received uproarious cheers and applause.

She went on, “I do think a system that allows billionaires to exist — when there are parts of Alabama where people are still getting ringworm because they don’t have access to public health — is wrong.” Here she insinuates that an entrepreneur possessing billions of dollars’ worth of wealth somehow contributes to those Alabamans being too poor to receive adequate protection from, and treatment for, ringworm.

Sen. Ocasio-Cortez’s answer made headlines. It became apparent that many people in the United States and other countries agreed wholeheartedly with it. Almost as famously as his boss, AOC’s policy advisor and senior counsel Dan Riffle was quoted throughout the media proclaiming, “Every billionaire is a policy failure.”

Still more notorious than AOC is a man with seniority over her in the U.S. Senate, Bernie Sanders of Vermont. “There is something profoundly wrong,” he shouted in his announcement for his 2016 presidential run, “when in recent years, we have seen a proliferation of millionaires and billionaires [actually, ‘MILLIONAYAZ AND BILLIONAYAZ’] at the same time as millions of Americans are working longer hours for lower wages and we have shamefully the highest rate of childhood poverty of any major country.”

Note the implication here — as with Sen. Ocasio-Cortez — that the “lower wages” and “child poverty” are at least partially caused by this “proliferation of millionayaz and billionayaz.”



That billionaire entrepreneurs have such an unflattering image can be seen even in attempts to compliment them. Such can be gleaned a video essay by pop-culture commentator Lindsay Ellis. Despite her overall sympathies for the anti-capitalist message of the computer-animated movie adaptation of Dr. Seuss’s The Lorax, she found herself vicariously embarrassed that it was presented in such a ham-fisted manner. In a gesture of perfunctory evenhandedness, Ellis states what she apparently considers to be the strongest argument in favor of for-profit commerce: “...corporations employ people and make us stuff — not useful stuff, but stuff.”

The triteness of her evaluation would not be so concerning, except that it seems even many of the most prominent “defenders” of free enterprise tacitly agree with this characterization. The best that can be said of market economics, it is believed, is that businesses “make us stuff,’ stuff that is “not useful.” The run-of-the-mill defense of capitalism is that it incentivizes the production of “stuff” much more effectively than do the State-owned enterprises of socialism. Socialism might manufacture not-useful stuff, but capitalism elicits much more competence in the assembly of not-useful stuff!

And as entrepreneurs become billionaires by hawking this not-useful stuff, we are told, these same entrepreneurs add to “child poverty” and Alabamans “still getting ringworm” by hoarding all the wealth and resources for themselves.

As Ocasio-Cortez added in 2020, the billionaires “made that money off the backs of single mothers, and all these people who are literally dying because they can’t afford to live.”

Human beings are “literally dying” for the reason that billionaires “made that money”? It is no wonder their legacy is tarnished.

Yet there is more to this story. Uğur Şahin and Özlem Türeci — the scientific married couple who cofounded BioNTech of Germany — became billionaires from developing the first existing COVID-19 vaccine. Noticing this, entrepreneur Louis Anslow tweeted out a Time magazine cover featuring these two, and asked in his tweet, “Are you sure no one deserves to be a billionaire?”


Anslow’s is a worthwhile question. To explore it, this essay comes in two parts. Part One ascertains that there is indeed more that can be said for capitalism and entrepreneurial billionaires than that they “make us stuff.” That many of the free market’s putative advocates tacitly agree with Lindsay Ellis’s belittling of capitalism’s benefits can be inferred from what they have omitted from their “pro”-capitalism statements. What they refrain from stating plainly is that free enterprise — more than any other sort of political economy, socialist or otherwise — has provided the freedom and impetus for innovators to save, lengthen, and enhance human lives. Not just about making us “stuff,” capitalism saves lives. And that is the point that capitalism’s so-called proponents should be emphasizing. If capitalism’s lifesaving nature were obvious to most people, not even an ideologue such as Lindsay Ellis could have been so confident in stating, as a generally accepted platitude, that capitalism is all about producing “stuff” that is “not useful.”

Hence, Part One is a series of over seventeen case studies of this principle in action. Where they are available, the estimated number of lives that a for-profit enterprise saved shall be enclosed. Most of those case studies involve pharmaceuticals and medical devices, but there are other examples that are far less obvious. Electric heating, air conditioners, and even lasers save lives. It was capitalism that facilitated the invention, production, and adoption of these technologies.

Putting all of those case studies in a single blog post takes up a lot of space. Therefore, in this, the shortest version of the essay, I have done the following. This version includes the first two case studies — those of the COVID vaccine and a cancer drug — and then goes to an index of the additional case studies, such as those about implantable pacemakers, MRI scanners, smoke detectors, electric heating, and lasers. That index is followed by the final case study, that of how synthetic nitrogen fertilizer has saved two billion lives.
 
To Part One, a detractor can reply, “Yes, that entrepreneurs produce medical devices is nice. But as the Earth consists of a fixed quantity of nonrenewable natural resources, it follows that one person owning a billion dollars’ worth of resources means there is less for everyone else. In that respect, if someone invents a life-saving medical device and gains a billion dollars from that, a billion dollars’ worth of resources all going into the possession of this one man still adds to other people’s poverty and the premature death that it brings.”

Such an assumption fails to understand the actual nature of wealth — economic value — and its origin. Consequently, Part Two considers the prospect that there is no inherent limit to the amount of economic value to benefit human beings. Further, insofar as citizens are free and peaceful with one another, someone gains ownership over a billion dollars’ worth of resources to the extent that she created economic value that was of at least that much worth to others. Part Two also summarizes how capitalism contributed to boosting living standards overall, sometimes even in the poorest countries where the government allows for relatively little capitalism. Whereas Part One focuses on specific inventor-entrepreneurs whose efforts have saved lives, Part Two ends with a summary of how peaceable commerce, in total, saves lives on an international scale.

With that, we take a journey into the past two centuries of entrepreneurship and its lifesaving.



PART ONE: PROFILES OF LIFESAVING FOR-PROFIT ENTERPRISES | ^

Creativity in the Age of COVID | ^
The married couple of scientists, Uğur Şahin and Özlem Türeci, co-founded BioNTech in Germany and partook in a joint venture with the USA’s Pfizer to develop the USA’s first vaccine for COVID-19, one that is an mRNA vaccine. Various attempts have been made to attribute this success more to taxpayer funding than to the couple’s initiative. President Donald Trump tried to take credit for BioNTech’s achievement, proclaiming that it came from Operation Warp Speed, his administration’s program to provide federal funding to synthesize such a vaccine. Yet BioNTech and its American collaborator, Pfizer, did not receive money from this program.

Other parties have said that BioNTech owes its success €375 million (the equivalent of 425 million U.S. dollars) to BioNTech is what should be credited. Yet this grant was made in September of 2020. As Johan Norberg points out, BioNTech’s vaccine had already gone into Phase III clinical trials five months earlier. The actual R-and-D that went into the specific vaccine’s creation did not come from a national government.

Nor was the federal government particularly enthusiastic about the work of the academic biochemist who laid the foundation for such mRNA vaccines, Katalin Karikó. Her role in lifesaving did not net her the billions it did for her BioNTech employers Sahin and Türeci, but it did earn her millions. Moreover, her experiences should be a revelation to those of us who assume that nonprofit academia is generally more open to new ideas than are supposedly greedy for-profit corporations.

In the 1980s, Dr. “Kati” Karikó suffered under communism in her native Hungary. She and her loved ones had to escape. When she and her family came to the USA to start anew, they had no more than what she got from selling her car — the equivalent of $1,200, which she concealed inside her daughter’s teddy bear.

In 1990, the potential of mRNA vaccines had entranced the Hungarian emigrant, now at the University of Pennsylvania. To familiarize a patient’s immune system with the sort of virus that it had to fight, a more-conventional vaccine introduces the immune system to a dead or weakened version of the virus or just a piece of it. By contrast, the vaccines that interested Dr. Karikó would carry chemicals consisting of special instructions for the immune system. These instructions were a “message,” making the vaccine a “messenger” — the m in “mRNA.” The mRNA would instruct the immune system on how to construct its own copies of pieces of the virus. The constructs from within the body would acculturate the immune system with the attributes it needs to recognize in the virus to be targeted. Once the immune system comes into contact with the virus in actuality, it is equipped to identify the virus and pulverize it.

But much of the initial hopefulness over mRNA vaccines dwindled among academicians. When they were injected into laboratory mice, it triggered immune reactions so virulent that it killed the rodents. Dr. Karikó wanted to uncover the cause of this over-inflammation and rectify it. Yet hardly anyone else shared her enthusiasm. The grant proposals she wrote were denied consistently. Eventually in 1995, her department threatened to fire her if she did not accept a dock in pay and a demotion to adjunct professor. And this ultimatum coincided with her receiving a cancer diagnosis.

Dr. Karikó accepted the indignity of that demotion as she battled her cancer. Collaborating with her UPenn colleague Drew Weissman — whom she met as they both rushed to use a university photocopy machine — she searched for answers on what the difficulty was.

An experiment from 2005 brought one such answer. For the control sample, Karikó and Weissman provided tRNA (transfer RNA) to mice. The mice from the experimental sample received mRNA and, as usual, suffered the anticipated life-threatening inflammation. Yet the mice getting the mRNA were fine. The distinguishing factor came down to a single molecule, uridine, which was in the tRNA but not the mRNA. When a mouse’s immune system encountered tRNA, the presence of uridine signaled to the immune system to accept the tRNA as if it were something from the host’s own body. By contrast, on account of uridine’s absence from mRNA, the mouse’s immune system interpreted the mRNA as a foreign intruder — much like a virus itself — and this instigated the immune system’s overreaction.

To determine if this could be corrected, Karikó and Weissman conducted yet another experiment. This time around, they inserted a synthetic protein called pseudo-uridine — which is similar to uridine — into the mRNA. As hoped, the pseudo-uridine in the mRNA proved to be an adequate substitute. Against the odds, Karikó and Weissman had rendered mRNA vaccines safe for mice and humans alike.

Karikó and Weissman got their results published in the medical journal Immunity. Other than that, the rejection from academicians continued. They were still turned down for grants. It was the for-profit BioNTech and its rival, Moderna, which expressed interest in the results.

In 2013, Dr. Karikó pleaded with her UPenn department to restore her faculty position. She recounts that her superiors “told me that they’d had a meeting and concluded that I was not of faculty quality.” Having had enough, she informed her department that she would accept BioNTech’s offer to become the company’s senior vice president. There, she would try to apply the information she gathered. These university bureaucrats laughed at her and then cracked, “BioNTech doesn’t even have a website.”

Those smug university administrators are not laughing now. Dr. Karikó patented her work, licensing it to both BioNTech and Moderna.

She says she now has a net worth of around $3 million. That is far less than what the company’s cofounders have, but when it comes to justice for this woman, it is a start.

And Şahin and Türeci are not the only scientists to have become billionaires from producing and providing a COVID vaccine. The same happened to figures associated with Moderna as well, mostly from the appreciation of the shares they had purchased at the company’s founding.

Among those to gain a billion from such appreciation is the company’s president, Stephen Hoge. A medical doctor, he was also hands-on in leading the R-and-D team that assembled the vaccine with longtime experts from academia, Barney Graham and Jason McLellan. Consistent with Dr. Karikó’s discoveries, Moderna was able to have the messenger RNA synthesize pieces of the virus. But there was still one crucial piece for which another technique was imperative. This was the spike protein with which SARS-CoV-2 enters human cells.

Hoge had the team apply the proposal of McLellan and Graham that when it came to getting the immune system to guard against SARS-CoV-2’s spike protein, it was sufficient to introduce to the immune system a substitute that was similar enough. That came from the MERS virus (Middle East Respiratory Syndrome), which McLellan and Graham had studied for years.

Three of the other people whom Moderna had made into billionaires were early investors. Very prominent among them is Moderna’s chair, Noubar Afeyan.

Afeyan is, like Uğur Şahin, an immigrant to the West from a Muslim-majority country. Had modern nationalist movements prevailed in their stated objectives, and no immigrants from Muslim-majority countries were able to reach the West, it would have reduced the likelihood of the world having available this weapon against the pandemic.

Trained in chemical engineering, Afeyan coauthored numerous academic papers. He is named as an inventor or co-inventor on over 100 U.S. patents. These often involve new processes to be implemented in the biomedical sciences. His experience in biotechnology and pharmaceuticals has given him insight on which firms and projects in these industries will make for promising investments. Through his venture capital firm Flagship Pioneering, he became Modern’s principal shareholder. 

Timothy Springer was another one of those initial investors who placed cash directly into Moderna. As Forbes reports, “Springer was a founding investor of Moderna in 2010, when he put about $5 million into the company. Now, a decade later, that initial investment is worth nearly $870 million.” Langer as well, says Time magazine, was “one of the first” of Moderna’s direct funders. And even before their investments in Moderna, Timothy Springer and Bob Langer engaged in commercial ventures that improved health and human life.

In his early career as a researcher, Springer made important discoveries about integrins. As the Wall Street Journal explains, “Integrins snare immune cells from the bloodstream and shuttle them to the site of an infection or injury. In autoimmune disorders, they traffic immune cells that attack the patient’s own tissue.” Springer spearheaded the commercial development of drugs to block the integrins that cause one such autoimmune disease, inflammatory bowel syndrome. He also guided the commercial development of drugs based on findings from colleagues who had partnered with him. Herman Waldmann discovered the antibody, alemtuzumab (CAMPATH-1). Springer founded the firm LeukoSite to license Waldmann’s antibody to treat multiple sclerosis — often a cause of life-threatening complications — and leukemia.

Robert Langer got his start in healthcare as the protégé to a medical researcher who, like Kati Karikó decades later, would long endure as an outcast for contradicting the establishment and for pushing back on the prejudice against commercialization. In 1962, Harvard Medical School surgeon Judah Folkman arrived at the theory of angiogenesis. Per this theory, tumors attract blood vessels to themselves and, from this tissue, form their own vessels through which blood flows to nourish the tumors. Folkman concluded that if he could cut off their blood supply, he could weaken or kill the growths. Rather than acclaim for this eureka moment, Folkman was met with ridicule. Folkman having surgery as his specialty, his theorizing about cancer apparently had other academicians reacting as if he were intruding on the disciplines of others.

As it was with Dr. Karikó, Folkman went for years with no luck in obtaining research grants. Then in 1974, he won a ten-year grant of $23 million from Monsanto Corporation on the understanding that the company would have first crack at commercializing any practical medical applications that could be divined from his findings. This was the first instance where Harvard allowed a faculty member to submit a patent application. Dr. Folkman received several patents, and the commercialism antagonized his detractors all the more.

To test his theories, Dr. Folkman looked for some tool to deliver adequately the chemicals that would go into a tumor and destroy its blood vessels. Here he received the assistance of Robert Langer, then a graduate student working under him at Children’s Hospital Boston. The promise was in Langer’s artificial polymers, such as Silastic. A major difficulty in healthcare is the administering of a drug in the proper dosage on a proper schedule. Langer placed a drug inside of a polymer casing that would then go into the patient’s body. By intention, the casing had many pores through which the drug would travel slowly as it made its way through the body. The drug would finally be released upon reaching the outermost pores. Langer designed the casing so that the proper dose of the drug would exit the casing and enter the patient’s organs at the proper rate.

Folkman had to run numerous experiments before settling on particular drugs and the proper dosages for them. In different tests, Langer’s polymer casing released the chemicals at different rates for study. Several drugs today are on the market that cut off the blood supply to tumors, a result of Folkman and Langer’s work.

Afeyan, Springer, and Langer took the millions of dollars they had earned from their prior lifesaving work and plunked these sums down into Moderna at its inception. The cash went to procuring for Hoge and his team the equipment and other resources that went with running the experiments whereby they developed their mRNA vaccine in competition with BioNTech’s.

Are the contributions of Şahin, Türeci, Hoge, Afeyan, Springer, and Langer to the commercial development and distribution of COVID vaccines enough to make them deserving of their respective billion-dollar fortunes? A team led by Alison Galvani of the Yale School of Public Health found that from January to November 2021, COVID vaccines had already saved 1.1 million lives in the United States. Likewise, data from 33 European countries evince that between December 2020 and November 2021, the vaccine saved a total upward of 469,000 people in these countries who were already above the age of 60.

Someone who was not integral to the formulation of this vaccine, but who was nevertheless helpful on COVID, is someone who already had over $100 million. That would be Jonathan Rothberg, the creator of an improved at-home kit whereby people can test if they have COVID and receive the results within one hour.

Rothberg first gained renown for combining his expertise in both biology and information technology. He thereby made a splash in “biometrics” — to take a reading of someone’s health by having the effects of her body be inputs scanned by a machine into its computer that interprets and processes the data. This is crucial to discerning the genetic sequence of a human being or any other lifeform.

In the 1970s, Fred Sanger needed four years to sequence the genome of a virus As the twentieth century transitioned into the twenty-first, scientist-entrepreneur J. Craig Venter and his rivals at the federal government’s Human Genome Project spent eighteen years on drawing a generalized map of the human genome. As of this writing, it now takes two days to gain a more accurate model of a specific person’s DNA sequence. Innovations on Rothberg’s part contributed to that final development. And once your DNA is sequenced, it becomes easier to identify the heritable diseases for which you are most at risk. According to an important chart by the firm Aperion Care — one the World Economic Forum featured on its official website, and which we shall discuss further later — this gene mapping saves five million lives annually. Work on this matter accounts for the affluence that Rothberg earned in the earlier portion of his career. Through his prior map of the human genome, Craig Venter cultivated a fortune as well. The New York Times announces, “He estimates that his net worth is in the tens of millions of dollars, even after giving more than $100 million” in shares of his companies “to endow his research organization, which is now called the J. Craig Venter Institute.”

By the spring of 2020, Rothberg then found himself concerned about COVID’s spread. There were two ways for technicians to determine if someone was carrying the virus. The more accurate method was the PCR test, and it took days for its results to come out. Given the relatively long wait, someone’s results could come back negative by the time that she went out again and contracted the virus after all. The other testing method involved antigens. The results of these tests could arrive in a day but their accuracy was often questionable, missing over one out of five positive cases.

Already a multimillionaire by then, Rothberg sought to place the quick response of the antigen tests together with the greater accuracy of the PCR ones. The team he assembled had formulated what was known as PCR-like molecular test. This new test could deliver accurate results within the hour. Starting in November 2021, Rothberg made these tests available to households, pricing them at fewer than $60 per unit.

As COVID’s Omicron variant spread throughout the world, Rothberg’s product became especially sought-after. And noteworthy about Rothberg’s efforts is how they undermined a form of symbolism that has long been exploited to denigrate capitalism. The giant yachts owned by the world’s richest citizens are frequently cited as physical representations of billionaire decadence. As Sen. Ocasio-Cortez would have it, people are “literally dying” from being deprived of the same resources with which billionaires gift themselves needless toys such as these. Yet Rothberg’s “superyacht” played a grand role in his lifesaving.

Rothberg and his children were sailing when the lockdowns of March 2020 began. Fortunate for everyone, Rothberg has his own laboratory on this vessel. From the lab of the yacht where he quarantined, and relying heavily on telecommunication, Rothberg marshaled his team of scientists, engineers, and technicians in bringing his accurate, rapid-result COVID test into reality. This yacht owner’s initiative is a great addition to the work of those who brought us COVID vaccines.

Uğur Şahin, Özlem Türeci, Stephen Hoge, Noubar Afeyan, Timothy Springer, and Robert Langer helped create a product and service that saved over a million lives and, in turn, each became a billionaire. I consider that justice. And this is far from unique when it comes to healthcare companies in particular and to capitalism in general.

Yet such an idea sounds strange to the general public. The common interpretation is Ocasio-Cortez’s: masses of people are “literally dying” because businesspeople “made that money”. Big Tobacco, which sells snack food as well, hooks its victims on nicotine. We are told that the billionaire Sackler family knowingly pushed senior citizens to become addicted to opioids. Even the bestselling self-help guru Robert J. Ringer, who has publicly praised Ayn Rand and free-market economics, approvingly quotes a “friend” in pronouncing that “the greatest mass murderer in history” was not “Adolf Hitler” or “Joseph Stalin” but “Ray Kroc.” Ringer blames the McDonald’s maestro for putting out hamburgers that that “succeed year after year in piling up impressive fatality numbers that would make run-of-the-mill serial killers envious.” The reader may therefore be surprised that abuses are the exception. It is shameful that Lindsay Ellis can go unchallenged, for years, in her assumption that the best that can be said of capitalism is that enables corporations to “make us stuff — not useful stuff, but stuff.” She should have been asked immediately whether she considers pharmaceuticals and medical devices to be “useful stuff.”

The remainder of Part One of this essay shall provide case studies of for-profit initiatives saving lives and enriching the entrepreneurs in the act. Most of these case studies involve pharmaceuticals or medical devices, but not all. Part One also gives examples of entrepreneurial innovations that are probably not so obvious in their lifesaving qualities. Not all of the entrepreneurs named have become billionaires; some of them did not even become millionaires by the standard of their time. However, all of them did attain financial successes by the standard of their era. And in all instances was it that commercialization was crucial to the lifesaving.

Because of space constraints, not all of the caes studies will be included in this particular blog post. Up next will be another case study, that of Patrick Soon-Shiong developing a lifesaving cancer drug. AFter that, the reader will find an index listing most of the other case studies. The reader can click on a link and go to a separate blog post featuring the story of that particular lifesaving for-profit venture. Below the index in this blog post will be one final case study: that of a fertilizer that hsa saved two billion lives.

When it comes to projects that tally the number of lives saved by inquiries like Dr. Karikó’s, or by other products, there are two that are especially helpful. One is a project started by science journalist Billy Woodward. It began as a nonfiction book of his, Scientists Greater Than Einstein, which profiled several scientists and their lifesaving discoveries. He employed a statistician to tabulate the number of lives saved by each discovery. Woodward then created the website ScienceHeroes.Com to promote the book.

Noticing that there are might have been discoveries and innovators that his book might have missed, Woodward continued researching and hired other experts to advise him. Sure enough, he was right. There were other wonderful accounts of history he had not known before, and he updated the site frequently to incorporate this new information.

The other illuminating project arrives from the health company Aperion Care, introduced in a web post by employee Heather Levine. This project tallies the number of life saved by various technologies. This index was cited by Jeff Desjardins for his website Visual Capitalist. This information so impressed experts that they had Desjardins’s essay on it reproduced on the official website of the World Economic Forum (WEF). In spite of the WEF’s founder speaking disparagingly of “neoliberalism” as a foil to the “stakeholder-based corporate social responsibility” that he prefers, this information on the WEF website gives a flattering impression of the creativity that “neoliberalism” fosters.

In the essay you are currently reading, the numerical figures on lives saved by specific drugs or medical devices are usually sourced to ScienceHeroes.Com. As for the figures on lives saved by other inventions, most of them come from the World Economic Forum’s write-up on the Aperion Care estimates.




Patrick and Paclitaxel | Patrick Soon-Shiong and His Cancer Drug | ^
Another lifesaving billionaire is Patrick Soon-Shiong, M.D. This story might seem, at first glance, to be one of taxpayer funding being the lifesaver. But soon Soon-Shiong arrives to provide the twist.

This tale began with the federally funded National Cancer Institute dispersing grants for the promising research of Monroe Wall and Mansukh Wani. From the bark of the Pacific yew tree, they derived the chemical that could be applied to treat cancer patients undergoing chemotherapy. Under the brand name Taxol, this chemical eventually went under the scientific name of just “paclitaxel” or “sb-paclitaxel.” This may initially seem an example of the superiority of government-directed investment over private enterprise, but the “sb” in “sb-paclitaxel” — sb for “solvent-based” — alludes to the difficulties with this treatment. On account of the complications with sb-paclitaxel, various scientists and businesses sought improvements over the drug. One was docetaxel, isolated by Pierre Potier in France. However, docetaxel presented similar problems.

To be administered in chemotherapy, sb-paclitaxel and docetaxel must be dissolved in a liquid called Cremator EL. Unfortunately, this solvent is toxic and impedes upon the patient’s ability to tolerate the medication. The patient must therefore consume other strong drugs, such as corticosteroid and antihistamines, to reduce the nausea that comes with either of these solvent-based taxanes.

This was where Patrick Soon-Shiong entered the scene. A medical doctor originally from South Africa, he had a bitter falling out with his brother and other investors over medical ethics. In 1985, Patrick’s brother and the investors tried to pressure him to perform a surgical operation under conditions that he considered unsafe for the patient. I previously blogged about this.

Patrick told interviewers in 2008, looking back, that the investors told him he should go ahead with the procedure and he will be penalized with nothing more than “a slap on the hand from the FDA.’ And I said, ‘No, that’s not all I’ll suffer. We’ll put patients’ lives at risk and I will not do it.”

Patrick was adamant. His brother and the other investors responded by suing him. Following that dispute and his move to the United States, the surgeon turned his attention to paclitaxel.

Patrick Soon-Shiong originally wanted to find a method for administering paclitaxel without the need to dissolve it in Cremator El. He looked to albumin, a chemical already found in the human body, being the most prominent protein in blood plasma. At the microscopic level, the doctor wrapped the paclitaxel inside an “envelope” of albumin. The paclitaxel was therefore administered to the patient inside this albumin “envelope.” Scientifically, this treatment went by the name of nab-paclitaxel — the NAB being for “Nanoparticle Albumin-Based.”

Although Soon-Shiong mostly wanted to make paclitaxel easier for patients to tolerate, it came with a fortuitous additional benefit. This new version, Hwaryeon Lee and company report in the journal Nature, turned out to be “more effective than the conventional solvent-based (sb) paclitaxel in the treatment of metastatic breast cancer.” In trials, the nab-paclitaxel outperformed the conventional sb-paclitaxel in the rate at which the metastatic breast cancer could be controlled and in terms of the patient’s ability to survive without the cancer progressing. William J. Gradishar and colleagues found in 2006 that metastatic breast cancer patients who received nab-paclitaxel even had almost double the overall response rate than did those receiving the conventional sb-paclitaxel. And Hwaryeon Lee and company add that the patients receiving the nab-paclitaxel also had a longer overall survival rate than those receiving the other alternative, docetaxel.

Soon-Shiong patented nab-paclitaxel and marketed it under the brand name Abraxane. The extent to which this drug outperforms conventional paclitaxel is the extent to which this man’s private and for-profit initiative saved additional lives. And this lifesaving made Soon-Shiong a titan of commerce. As of this writing, his net worth is $7 billion.

Soon-Shiong’s success in light of his refusal to perform that dangerous operation all those years ago highlights an important principle. The common assumption is that someone’s profit-seeking goes with a flagrant disregard for the well-being of other people. On that premise, one would assume initially that Soon-Shiong was sacrificing a profitable career when he refused to put that patient’s life at risk. Yet the truth is the opposite — malpractice on Soon-Shiong’s part would have damaged his credibility. Potential patients and later clients would have wisely avoided him, impeding on his moneymaking ability. It was to the very extent that he looked out for the best interests of patients that Soon-Shiong was able to win trust and build his company.




Index of the Other Case Studies of Lifesaving For-Profit Initiatives  | ^

To save space on this blog post, I have put all the other case studies, except the final one, in separate blog posts. Readers can choose for themselves which case studies they will or will not read, according to which sound the most interesting.

* Alex Ulllrich and His Biotech Cancer Treatment
* Herbert Boyer, David Goeddel, and Genetically Engineered Insulin
* Jennifer Doudna, George Yancopoulos, and Gene Editing
* Paul Offit and the Rotavirus Vaccine
* David Hamilton Smith and His Vaccine to Prevent Meningitis
* Wilson Greatbatch, C. Walton Lillehei, and Implantable Pacemakers
* Raymond Damadian and MRI
* Leo Baekeland and Plastics in Hospitals
* Percy Julian, Sr., and New Foam fore Fire Extinguishers
* Duane Pearsall and the Smoke Detector
* Thomas Edison, George Westinghouse, the Air Brake, and Electric Heating
* Gail Borden and Condensed Milk
* Thomas Midgley and Safer Air-Conditioners and Refrigerators
* Gordon Gould and the Laser




Fritz and His Fertilizer | Fritz Haber, Carl Bosch, and Synthetic Nitrogen Fertilizer  | ^
And, for the last, we have left the biggest lifesaver. Recall that a website frequently cited throughout this essay, ScienceHeroes.Com, was created by Billy Woodward to promote his book Scientists Greater Than Einstein. Although he describes himself as a “businessman” in the About the Author section, the book conveys its author’s unflattering impression of capitalism and for-profit enterprise.

Upon describing an action by Merck that he judges unethical, Woodward hisses that such an action is one “that those teachers who believe in Ayn Rand’s laissez-faire capitalism can teach in business schools and those who revere less the principle of selfishness can explore in ethics classes.” This disparagement is taken farther still on ScienceHeroes.Com.

The book’s final chapter argues that the private sector cannot and will not finance medical research adequately, and therefore there needs to be greater taxpayer funding of science. Woodward frames such “a choice for our future” as one of “Our Health” versus “Our Wealth.”

Yet in totaling the numbers of people saved by scientific projects, ScienceHeroes.Com provides information that is not completely consistent with Woodward’s generally unfavorable estimate of capitalist greed. The scientific endeavor that Woodward’s own website ranks as the one to have saved the most lives is . . . a for-profit venture.

This was the venture by Fritz Haber and Carl Bosch in the industrial production of synthetic nitrogen fertilizer. It is well described on ScienceHeroes.Com in two articles penned not by Billy Woodward but by one of the writers assisting him, April Ingram.

Even for reasons other than his commercialism, Haber is not someone who would normally be described as a humanitarian. Prior to the ascension of the Nazis, Haber was a fervent German nationalist, especially in matters of military conflict. During World War One, Haber eagerly assisted the German government in weaponizing chlorine gas to be dispersed on French soldiers. Yet, even considering his role as one of the founders of chemical warfare, Haber instigated a project that holds the record in number of lives saved.

In 1899, the British scientist Sir William Crookes warned that the farms of the West were exhausting all the nutrients of their soil. Soon, they would not be able to grow any more, and the starvation would result. Haber took this to heart. A decade following Sir William’s dire prediction, Haber formulated methods to produce synthetic fertilizer, ammonium nitrate. As an executive of BASF, Carl Bosch refined those methods and applied them on an industrial scale. This became known as the Haber-Bosch process, and it made its namesakes very rich.

Still, the ascension of the Third Reich doomed both these men. Although Haber was a Christian, the Nazis held his Jewish ancestry against him and banished him from practicing any science. This was a crushing blow to someone previously so worshipful of the German state. Bosch went to Adolf Hitler directly to plead on Haber’s behalf. The industrialist informed the führer that purging Jewish scientists would set the country back on physics and chemistry for a hundred years. To that, Hitler simply replied, “Then we’ll just have to work 100 years without physics and chemistry!”

As the Third Reich held a tight grip on the national economy, it was easy for Nazi officials to inflict reprisals on Germans who did not express sufficient enthusiasm for their governance. As Bosch was highly critical of the Nazis, he was gradually stripped of his duties at BASF. Bosch sunk into depression and alcoholism.

Even decades after their death, the process of Haber and Bosch continued to change the world. After the famines imposed by Mao Tse-tung’s communism, China under Deng Xiaoping applied the process and ended the starvation.

ScienceHeroes.Com admits that the for-profit venture of Haber and Bosch has saved “over 2.3 billion lives.” In a Wired article from 2013, Bill Gates informed his readers, “Two out of every five people on Earth today owe their lives to the higher crop outputs” that the Haber-Bosch process “has made possible.”

All of the cases we have studied were about someone becoming obsessed with some problem or mystery and, in an attempt to solve it, exercised creativity in such a manner that resulted in saving people’s lives. This gives the lie to the claim by famous anti-capitalist Noam Chomsky that it takes a “lack of curiosity and independence of mind...” for someone to reach “the high end” of “income distributions...”

A “lack of curiosity and independence of mind” sure does not describe Katalin Karikó, Jennifer Doudna, Percy Julian, Patrick Soon-Shiong, or any of the other innovators who struck it rich.



PART TWO: HOW, CUMULATIVELY, BILLIONAIRES SAVE BILLIONS OF LIVES | ^


Value Added to the Natural Resources | ^
The author hopes that by now the reader is convinced that there are many instances throughout modern history of for-profit enterprises contributing to the extension of lives and the comforts within them. Yet those who look askance upon capitalism and billionaires are probably not satisfied. They can proclaim that these instances of lifesaving by billionaires such as Patrick Soon-Shiong and George Yancopoulos do not remove an inherently self-destructive attribute from commercial activity.

It is frequently stated that the global economy runs on nonrenewable natural resources. Such nonrenewable resources include petroleum, coal, tungsten, lithium, and silicon. The total quantity of such resources used as raw materials in goods and services only grows annually. Once these resources are used up, it is said, that will be the end of civilization. The persistence of this belief is a major reason why millions of people nodded in agreement as activist Greta Thunberg went before the United Nations to prevail upon various heads of State to abandon their “fairytales of eternal economic growth.”

The belief also feeds into Alexandria Ocasio-Cortez’s looking wistfully on the prevailing bias against capitalism that intellectuals had in the period between 1930 and 1979. She longs for a return to that “one point in time” where there was “almost a full consensus among our greatest thinkers in America that capitalism had an expiration date. This Late-Stage Hyper-Capitalism society of ‘just accrue’? This capitalism as an ideology of capital? And that ‘our number-one goal is to maximize profit at any and all human and environmental costs’? They knew that the idea was not sustainable.”

If the amount of wealth and prosperity is nothing more than a direct function of the quantity of nonrenewable natural resources, then the amount of wealth that can be enjoyed does come in a fixed quantity. It may be said that even if Patrick Soon-Shiong’s development of nab-paclitaxel saved the lives of cancer patients, the benefits came at the expense of everyone else in society. The resources that went into fighting metastatic breast cancer, and that went into the big fancy toys that Soon-Shiong and Jonathan Rothberg bought for themselves, are resources denied to everyone else. If Soon-Shiong and Rothberg own and have direct access over a total eight billion dollars’ worth of resources, that is eight billion dollars’ worth of resources less for the rest of Earth’s human population, especially its poorest.

Hence Alexandria Ocasio-Cortez pronounces, “No one ever makes a billion dollars. You take a billion dollars.” (emphases hers).

And she continues that “this system that we live in — life in capitalism — always ends in billionaires. This thing that we live in, starves people.”

To wit, the richer the billionaire is, the more it “starves people.”

That capitalism staves people is an odd claim to the employees of agribusinesses. It would have been news to Carl Bosch.

Yet Dan Riffle, the policy advisor and senior counsel to AOC who stated, “Every billionaire is a policy failure,” reinforces his employer’s zero-sum interpretation. After pretending to understand that more economic value can be created, Riffle makes it known that he will continue to deny, arbitrarily, the logical ramifications of such a fact. That is implicit in his proclamation that “it’s certainly the case that the bigger Jeff Bezos’s and Bill Gates’s slices of the pie are, the smaller everybody else’s slices of the pie are going to be.”

This is the same idea behind Bernie Sanders’s notorious proclamation, “You don’t necessarily need a choice of 23 underarm spray deodorants or of 18 different pairs of sneakers when children are hungry in this country.” Bernie’s presumption is that the resources that went into producing the twenty-three different types of deodorant and eighteen models of athletic shoes were resources that otherwise would have gone into feeding kids starving in the USA. The number of choices in hygiene canisters and fancy footwear is inversely proportional to the ability of America’s youngsters to have enough to eat.

The belief has been expressed by Percy Bysshe Shelley in words that would become cliché soon after they were published: “The rich have become richer, and the poor have become poorer...”

That slogan’s enduring popularity derives from a flagrant misunderstanding of the nature of wealth. The wealth that distinguishes a grand living standard from an inadequate one has less to do with monetary units than with the goods and services for which those monetary units are exchanged. More than that, that wealth is not an inherent function of the quantity of nonrenewable natural resources available. Instead, wealth is in the efficiency of the methods employed to derive life-enhancing value from such resources. It is therefore fitting that the term capitalism comes from “capital,” which has its origin in the Latin capita, meaning “head.” It is fitting because entrepreneurial innovators must use their noggins to conceive and implement such strategies to improve the efficiency by which the natural resources are used.

Alexandria Ocasio-Cortez blares, “Usually if you’re a billionaire, it means that you control a massive system. It means that you own oil supplies. . . . And to be ethical — if you’re a billionaire today — the thing you need to do is give up control and power” over those resources.

She talks as if petroleum was always inherently worth being in everyone’s control collectively, and then a small cabal of billionaires came and usurped that control all for itself. In reality, the default was a gallon’s worth of crude oil in the Stone Age and even the 1700s was of relatively little advantage to anyone. From the Middle Ages to the eighteenth century, farmers hated it when they found the black sludge. The foul-smelling goop seeped and damaged their crops. The presence of oil on their land only reduced marketplace demand for the property. Striking oil only became a plus and not a minus when Canadian geologist, chemist, and entrepreneur Abraham Gesner discovered and publicized the properties of petroleum that made it an ideal as a source of fuel, one rivaling the utility of whale oil.

That is, a gallon’s worth of crude did not have an inherent value. It gained value subsequent to the fulfillment of two conditions. The first condition was for a scientist such as Gesner to apprehend how that crude oil can be made useful for human beings. And even the fulfillment of that first condition, by itself, was not enough. Once Gesner established that kerosene could be isolated from crude, and that kerosene could light a lamp, that still would not ultimately help anyone who wanted to light a lamp if not for someone bothering to separate the kerosene from the rest of the gunk.

There was nothing obvious about it. That brings us to the second condition that had to be fulfilled for the petroleum to become valuable — someone had to bother undertaking the task of separating the kerosene from the crude and bringing it to market. As anyone with unfulfilled dreams can attest, dreaming up a great plan is a cinch in comparison to following through on it and keeping the commitment. In this instance, someone had to bother setting in motion the separation. That took the planning and organizing conducted by entrepreneurs such as Gesner and George Bissell, and which was taken to a more sophisticated level by John D. Rockefeller, Sr.

Nor was it obvious to Stone Age people that sulfur could be of use to them. It was a nasty, foul-smelling chemical. It took forward-thinking entrepreneurs to transform such a con into a pro. The German chemist Herman Frasch had such foresight, and developed methods both for pumping large quantities of sulrf from deposits and for extracting the sulfur from crude oil so that kerosene could be refined.
This newly accessible sulfur turned out to be an important ingredient in the first widely used antibiotic, sulfa, which went by the brand name of Prontosil. This medication saved thousands of soldiers’ lives during World War One. As a consequence of Frasch’s achievements, Rockefeller purchased his patents and made him Standard Oil’s director of research. The German’s net worth at the time of his death in 1914 was $5 million, $128 million in 2018 U.S. dollars.

And this principle applies to so much more than petroleum and sulfur. 

It was not obvious to the ancient humans who first encountered petrified tree sap that one day it could be placed in telegraphs to have them transmit electrical signals. Nor was it obvious to the first caravans that the sand over which they traveled could be converted into cables that one day would enable one person to communicate instantly to someone else on the other side of the planet. And it was not obvious to the humans who first observed lithium that such a metal would be an excellent conductor in tiny rechargeable batteries powering telephones and computers fitting in their pockets. Nor was it obvious that such a metal one day would be invaluable to keeping hearts pumping, as do the lithium-iodide batteries in Wilson Greatbatch’s implantable pacemakers.

The extension or improvement of life that someone gets out of a good or service is what can be called “economic value.” That is wealth in its most direct form. And this economic value is not fixed and intrinsic to units of natural resources. It is instead to be found in human methods for making use of those resources. 

That the the entrepreneur’s planning and coordination of production adds a net increase in value to resources is an important consideration missing from AOC’s tirades. If more than half of the oil resources are controlled by entrepreneurs such as Gesner and Bissell, and later Rockefeller, it is because they are the ones who made the hard choices that gave more than half of the oil resources the value that they have.

And as efficiency improves, a person can obtain just as much — or even more — economic value from a good or service even as smaller quantities of resources need to be used up in the provision of this good or service.




Natural Fact One (of Two): Resource Substitution | ^
Insofar as individuals are free to enterprise peaceably, several facts of Nature guard against the depletion of resources. The first fact is that many different types of resources can be applied for the same use. That means that as one resource used for a particular purpose grows scarcer in current availability, human beings can switch to an alternate resource to substitute it. For much of the nineteenth century, people harvested liquids from sperm whales to light their lanterns. It was as whales grew scarcer and their oil gained in price, that Abraham Gesner discerned that kerosene could be marketed as a cheaper substitute. And copper provides another example.

Since the nineteenth century, copper wire had been used to conduct electricity in telecommunications equipment. It was in telegraph wires and then telephone lines and eventually in satellites. From 1960 to 1969, the price-per-pound for copper climbed, in 2020 U.S. dollars, from $2.83 to $3.35. This motivated firms to search for a cheaper substitute. In 1970, three engineers from Bell Laboratories found it in the form of fiber-optic cables made from glass that itself came from sand. To this day, copper continues to be installed in satellites and other telecommunications equipment, but many parts previously cast from copper have been replaced by the fiber-optics. The inflation-adjusted real price of copper then decreased again. By 1990, copper was priced, in 2020 U.S. dollars, at $2.44.

This ability to make use of substitutes has done well to hold off the depletion of resources.

The excellent 1987 book The Doomsday Myth, by Charles Maurice and Charles W. Smithson, provides case studies of such a phenomenon throughout history. During the 1600s, the British stopped burning wood to heat their homes and opted for coal. In the late nineteenth century America, railroads used less timber for tracks and used more iron and steel. Amid World War Two, the shortage of rubber trees led American engineers to produce synthetic rubber from petroleum. It was also from this book where I learned the details of whale oil being phased out in favor of kerosene to light lanterns.

Even the advent of agriculture illustrates this principle. For ancient hunter-gatherers, the price of food was the hard work it took to hunt and forage. This drove many species to extinction, and led to food shortages. The cheaper substitute was for the farming of grains to become the main source of sustenance.

Interestingly, the real price of copper has again ascended throughout 2021 and 2022. Insofar as engineers are free to innovate, we may again witness engineers devising still other replacements for copper in machinery.




Natural Fact Two (of Two): Greater Utility From Fewer and Smaller Inputs | ^
Yes, continue the enemies of capitalism, human being can use their engineering know-how to substitute a scarce resource with a more plentiful one. Still, they ask, how does economics reward entrepreneurs from guarding against the depletion of nonrenewable natural resources on the whole? The answer has to do with the entrepreneurs’ costs being a function of the quantity of natural resources they drain. Thus, we come to the second pertinent fact about preventing the depletion of resources. As humans gain a greater degree of scientific knowledge about their resources, they are indeed able to improve the efficiency of how these resources are expended. And this principle applies even when a more abundant resource cannot be acquired as a substitute for a scarcer one. 

The economic value that a business produces for its customers is called “output.” “Inputs” refer to the resources that must be used up in the process of generating the output. Inputs include both human labor and the natural resources that the operation entails.

As a firm must trade its own assets to acquire any input, every input adds to the firm’s expenses unless the firm is able to shift such expenses forcibly onto other parties. One example would be for the firm to steal its resources from someone else. That is consistent with the caricature of corporations being evil, but it actually clashes against the very principle of capitalism. Capitalism is contingent upon the enforcement of private property rights. To the extent that a firm coercively plunders someone else, the firm behaves in opposition to capitalism itself. Plunder is stopped to the extent that private property rights — and, with them, capitalism — are enforced consistently. We shall revisit that principle by the essay’s end with respect to pollution and industrial contributions to climate change.

Another method whereby a firm can elude paying the costs of its inputs is for the firm to receive direct taxpayer funding. Insofar as the firm successfully lobbies for this to happen, the firm is redirecting its own expenses onto the taxpaying public. This coercive redistribution is not pro-capitalism nor is this even, as it is often pegged, “pro-business,” “pro-corporation,” “corporationism,” or “corporatocracy.” The costs of a particular business or corporation may be reduced, but this is the result of resources being snatched from the owners of still other businesses and corporations. It is illogical to label this as if it were free capitalist enterprise, as that coercive intrusion leaves those other parties unfree to capitalize on their own enterprise. That is not pro-business any more than the State privileging one human at the forcible expense of another is “pro-human.” In effect, inasmuch as we want businesses to pay their own way, we must oppose direct taxpayer subsidies to them, even ones that perform work as salutary as Moderna’s.

To the extent that people are free and their private property rights are enforced, every input in an entrepreneur’s operations imposes a cost upon that entrepreneur. Thus, the entrepreneur downsizes her costs, and thereby upsizes her profits, insofar as she employs new techniques for producing at least as much economic value as she did before from ever-smaller and ever-fewer inputs of labor and natural resources. And she can also cut costs by producing at least as much economic value from smaller and fewer inputs of tools and machinery. Those tools were created by still other entrepreneurs in prior efforts at coordinating the laborers’ interactions with the natural resources. Hence, everything ultimately comes down to getting more value out of smaller quantities of labor and natural resources.
↑ Profit = Economic value to customers (Revenue from sale) – ↓ Cost of natural-resource inputs
That involves the development of technologies that improve efficiency. 

Since the late twentieth century, this argument has been most commonly associated with economist and business management professor Julian L. Simon, first in 1980 in the journal Science and then more famously in his classic book The Ultimate Resource. However, he was not the first intellectual to advance it. Decades before him in Denmark, from her own research the agricultural economist Ester Boserup induced similar insights. The power of her arguments has been noted even in the Proceedings of the National Academy of Sciences (PNAS). And the general idea behind the argument was advanced over a century earlier by Jean-Baptiste Say in a series of letters he wrote to that prophet of resource depletion, Rev. T. Robert Malthus. These letters were published for the public in 1821.

Such arguments have often been written off by the establishment. But someone co-won the 2018 Nobel Prize in economics for making a very similar case in mathematical form, Paul Romer. Romer is much fonder of taxpayer-funded basic research than Simon was, and there are issues with his presumption that scientific knowledge is a “public good” that cannot and should be privatized. Still, Romer is entirely correct in agreeing that the application of the human mind to improving efficiency in resource usage is the true creator of economic value and that it does the opposite of deplete mindlessly all the Earth’s resources.

Frustratingly, such considerations do little to deter those of a particular political ideology from intoning ominously that the size of the human population will outstrip the Earth’s bounty. These people dismiss, as naïve, the notion that firms can simply boost their profits by improving efficiency and reducing waste. Those people scoff because they grossly underestimate the extent to which, throughout history, such efficiency improvements and waste reductions have been a major source of growth in profits.

A case study of this is to be found in the evolution of electric dynamos. The power plant that Thomas Edison finished constructing in 1882 on Pearl Street in Menlo Park, New Jersey, had six Jumbo dynamos. Each of these dynamos weighed 54,000 pounds and generated 100,000 watts. That is 1.85 watts of electricity generated per pound of machinery. By contrast, a gasoline-powered 10,000-watt dynamo constructed by the firm Briggs and Stratton in 2020 generated 34.7 watts per pound.

Edison’s total investment in the Pearl Street power plant was $600,000. In 2020, U.S. dollars, that comes to $17.28 million. Hence, Edison generating 600,000 watts would cost him, in 2020 U.S. dollars, $28.80 per watt generated. In 2020, an entrepreneur could buy sixty Briggs and Stratton generators, each for $2,000. For that entrepreneur in 2020, generating a single watt of electricity would cost 20 cents.

Here we find that, due to efficiency improvements, a single pound’s worth of material comprising a dynamo in the year 2020 could generate more than eighteen times as many watts in electricity as Edison’s dynamos could, and at less than one percent of the cost.

And that is far from all. Consider the nonrenewable natural resource that is coal. Every few years during the early twentieth century, engineers introduced another model of coal-burning machinery that exerted greater thermal efficiency than did the older models. In the year 1900, more than seven pounds of coal had to be burned to power a 100-watt lightbulb for one hour. By the year 2000, for that same lightbulb to perform that same task required burning less than a single pound.


That principle can be expressed through other figures. Lumens are the units by which light is measured. In the year 1898, one watt powering an incandescent lightbulb would produce six lumens. In 1920, that watt produced ten lumens. In 2003, it would be 200 lumens.

That is less and less coal per lumen.

Recall the point from earlier about Edison’s dynamos. In 1898, a single pound’s worth of Edison’s dynamo would generate 11.16 lumens. By 2003, a single pound’s worth of a Briggs and Stratton dynamo could supply 6,940 lumens. In a little over a century, then, the number of lumens generated by that single pound of material had grown over 600-fold.

Indeed, steel has been used more efficiently over the course of the century. Over 68 percent of the steel put to work in the U.S. economy is recycled annually. When this alloy is newly produced and is being installed for the first time, it is called “virgin steel.” That is treated more economically as well. Steel still goes into automobiles, but not exactly in the same fashion as in previous decades. That is one reason why the weight of automobiles dropped by one fourth between the years 1970 and 2001. For such reasons, between the years 2000 and 2015, even as there was an increase in the quantity of products containing steel, total use of the alloy in the United States fell by 15 percent.

Virgin steel is set to work more efficiently than before and, in turn, it is produced more efficiently as well. Producing steel has always required that iron be heated to the extent that it takes on a molten form. At the opening of the nineteenth century, producers had to burn an average seven tons of coal to churn out a single ton of “blister” steel. This changed in 1856 with inventor-entrepreneur Henry Bessemer introducing the process named for him, wherein cold air would be blasted upon the super-heated iron. Then it took no more than 2.5 tons of coal, in super-heated “coke” form, to finalize a ton of higher-quality “crucible” steel. By the year 2020, putting out that same ton of steel required less than 0.86 tons of coal.

And coal is not the only resource being inputted more economically in steelmaking. Between the years 1930 and 1949, making a single ton of steel cost an average 200 tons of water. That figure decreased to 20 tons by the 1980s. By 2018, the most efficient plants could make a ton of steel from three to four tons. For-profit enterprises have produced technological improvements that conserve water in other aspects as well. Before 1997, the Oberti Olive Plant had to deplete over 10,000 gallons to turn out a single ton’s worth of product. Between 1997 and 2002, the same plant only had to consume 859 gallons to deliver that same ton.

In decades past, the flush of a toilet drained an average 20 liters. In 2018, that same flush drained six liters or fewer.

For most of the USA’s history, the total quantity of water used daily steadily increased. But that peaked around the year 1975 at 425 billion gallons per day. From then on, the quantity of water Americans washed down daily remained relatively stable, even as the population and industrial output both grew. From 1984 to 2004, the USA’s per-capita water usage actually dipped by twenty percent.

Click on this to see the website it is from.

In the 1970s, every cubic meter of water consumed in Hong Kong generated an average 500 Hong Kong dollars’ worth of economic value. Adjusting for inflation, by the year 2000 that same cubic meter of water yielded twice as much Hong Kong dollars’ worth of wealth. Figures from the heavily populated areas of the United States point to a coinciding trend. In the year 1975, every cubic meter of water inputted for industrial purposes yielded, in 2004 U.S. dollars, an average eight dollars in utility. By 1999, also in 2004 U.S. dollars, that figure doubled.

Gasoline is another nonrenewable input that the market conserves. The inventor and engineer Soichiro Honda, for whom the famous auto company is named, thought that motorists deserved more out of their driving experience. He assembled a team of engineers, including future Honda president Tadashi Kume, to put out a more economical car, the Honda Civic with its CVCC engine. In 1973, before the CVCC engine existed, a motorist could travel 12.9 miles on a single gallon of gasoline. Starting in 1975, upon release of the CVCC, that same gallon would take that same motorist six miles farther. In 2014, that same gallon would take a car farther than 21 miles.

Click on image to see website it came from.

The trend has continued with electric vehicles. When the Tesla Model S came upon the market in 2012, it had a range of 250 miles per charge. By contrast, the Tesla Model S with a Long Range Battery Pack from 2021 had a 390 mile range per charge. Complementarily, in the Nissan LEAF, between 2011 and 2020 the range almost tripled with the number of miles per charge increasing from 73 to 215.

The automobile engines of 2002 were twice as powerful as were those from thirty years earlier. Yet they emitted half as much in exhaust fumes.

 Other modes of transportation undergo the same evolution. Compared to one from 1970, a Boeing 747 commercial airliner in 2002 was half as loud and consumed 17 percent less fuel even as it worked at a quarter more horsepower at takeoff. In the duration of 1960 to 1990, the thrust-to-weight ratio in commercial jet engines increased from 4.2 to six. Similarly, between 1940 and 2000, the thrust-to-weight ratio of the gas turbines in these same airplanes lifted from 15 percent to more than 40 percent.

Pollutants that firms release into the air and water are waste byproducts — those are the part of the input that cannot be put into production. As firms gain in efficiency and put every part of the natural-resource input into production, that reduces the waste and therefore reduces the pollution. That is why in both the United States and United Kingdom, firms had been reducing their emissions of toxins in the air even prior to these countries each passing their own particularly strict Clean Air Act.


A doubter might say, “Maybe for every unit of a good produced, less of a particular substance is used. But it doesn’t follow that, in the end, smaller quantities of matter as such are used per unit produced.” Actually, it does follow. That is demonstrated in the reduction of the total mass per unit for particular goods.

A ten-story office building constructed in the year 1999 weighed less than one constructed in 1890. Former Federal Reserve chair Alan Greenspan explains the reasons for this. “Advances in architecture and engineering, as well as the development of lighter but stronger materials, now give us the same working space but in buildings with significantly less concrete, glass, and steel tonnage than was required in an earlier era.”

In 1992, he also noted, “Our radios used to be activated by large vacuum tubes; today we have pocket-sized transistors to perform the same function.” The development of these transistors was responsible for an even more drastic change in the size of computers.

In the 1950s, a mainframe would take up the space of an entire room, sometimes even an entire building. In 2020 U.S. dollars, the cost of assembling and maintaining such a machine was in the millions. A single digital watch today priced at $35 exercises more computing power than did any of those mainframes. A pocket calculator from the year 2000 already computed 350 times faster than did the computers involved in the Apollo 11 mission. Inventor-engineer-entrepreneur Ray Kurzweil makes an even more impressive comparison. He says that in the 1970s, considering the state of technology at the time, it would have taken trillions of U.S. dollars’ worth of resources to build a computer with the same amount of computing power as those of the smartphones that African villagers were carrying around in 2013.

Speaking of mobile phones, from 1990 to 2011, the average weight of one shrank from twenty-one ounces to four ounces. That is, a mobile phone from 2011 was less than one-fifth the weight of one from two deaces prior. Much of this trend has to do with the aforementioned improvements in efficiency of the lithium-ion batteries inside these mobile devices. Between 2008 and 2015, the quantity of kilowatt hours generated per liter of lithium-ion doubled from 200 to 400. And between 2010 and 2017, the quantity of watt hours per kilogram of lithium-ion almost tripled from a little over 100 to 300. Stated in other terms, a mobile phone manufactured in 2015 could perform the same tasks as one from 2008 on just half the amount of lithium.

Using the weight as a proxy in measuring mass, we can discern that a particular product today can produce the same output as that product’s counterpart from decades ago even though the product of today uses up a smaller quantity of mass from natural resources.

That is visible wuth someone we mentioned earlier, that of Jonathan Rothberg and his portable and wheeled MRI machine, the Hyperfine Swoop. Compared to a standard MRI scanner from 1977, Rothberg’s Swoop is ten times lighter in weight and consumes 35 times less energy.

This likewise happens with household tools. The first power drills came out in Germany in 1895. Each weighed seventeen pounds and was only slightly more powerful than a hand-cranked drill. To operate it, someone had to grab its two handles and hold it up to one’s chest. The on-off switch was far away from the machine. To turn it off, the operator had to take his hand off the tool itself. That way, the operator could lose control of the machine and injure himself. In 1917, the American inventors Samuel Duncan Black and Alonzo G. Decker, Sr., introduced a variant that was eight pounds — less than half that of its predecessor — and was easier to use. It had a trigger like a gun that, when pulled, turned the drill on. They priced it at $230, which is over $5,000 in 2020 U.S. dollars.

By 1921, Arno H. Petersen made a version that was still more ergonomic. Instead of putting the trigger where it would go on a gun, Petersen put it on a handle behind the motor. This put less stress on the forearm of the person operating it. And it was four pounds, and sold each unit at $42. That is $609.32 in 2020 U.S. dollars. Petersen’s version, christened the “Hole Shooter,” serves as the general model for those being manufactured in 2022, being roughly the same weight and largely the same in design. In short, the power drills at the time of this writing generate the same output as those from 1895 but are less than a quarter of their weight and sell for less than one percent of their real price.

In 2001, science journalist Ronald Bailey provided other examples of consumers receiving the same or greater economic value from products that consisted of less mass, overall, than did their counterparts from prior decades. That year, food cans were half the weight that they were in 1951. Likewise, plastic soda bottles were only seventy percent the weight of those being sold in the 1970s, and the ones from the 1970s were already lighter than the glass bottles they replaced. And Ronald Bailey returns to our example of copper wire in satellites giving way to fiber-optic cables.
A copper wire can transmit 24 voice channels or about 1.5 megabytes of information per second. Far thinner and lighter optical fiber can transmit more than 32,000 voice channels and more than 2.5 gigabytes of information per second. The first American communications satellite, Telstar 1, was launched in 1962 and could handle 600 telephone calls simultaneously. Modern Intelsat satellites can handle 120,000 calls and 3 TV channels at the same time.
Alan Greenspan observes that this even happens with our clothing. “The development of the insights that brought us central heating enabled lighter-weight apparel fabrics to displace the heavier cloths of the past.”

We can dispel any notion that the reduction in the quantity of one category of natural-resource inputs in every unit produced simply shifts to an increased used of a different natural-resource input for that unit. We can do so by examining how much energy altogether is expended on creating an average unit of economic value. This can be done by looking at overall energy intensity. This is how much energy in total — coal, oil, nuclear, and renewables combined — go into the production of economic value. Energy intensity measures the quantity of megajoules that had to be generated to produce an average inflation-adjusted dollar’s worth of economic value. A reduction in the energy-intensity ratio over time means that smaller and smaller quantities of natural resources must be converted into energy to generate the same amount of economic value.

And that is what we find. From 1880 to 2000, the number of megajoules that had to be generated in the USA to bring forth a constant 1990 U.S. dollar’s worth of economic value shrank from 50 to 15. For the United Kingdom in the year 1830, 35 megajoules had to be generated to produce a constant 1990 U.S. dollar’s worth of value. By the year 2000, it was 15.

Click on image to see website it is from.

It may be said that even if a specific unit of a good has shrunk in mass, such as computers getting smaller, the total quantity of natural resources consumed annually has expanded on account of the number of units produced growing annually as well. But, no, the improvements in efficiency have even preempted a major increase in the total quantity of natural resources consumed per year.

Economists calculate the weight of all the goods and services circulating through the U.S. economy. Once again, we use the weight of objects as a proxy in measuring their mass. Alan Greenspan notes that since 1977, the estimated real goods output of the United States annually has maintained a relatively stable weight.


It reached high points of 1.2 billion metric tons in the separate years of 1979 and 2013.

Rockefeller University scholar Jesse Ausubel writes that among 100 commodities studied by Paul Waggoner, Iddo Wernick, and himself, the total annual usage of 36 of them —including steel, timber, paper, asbestos, and chromium — peaked in 1970 and then dropped off since then.

All this happened even as the American economy experienced a net growth since 1979. The increase in wealth is due not to the natural resources themselves as much as how smartly those natural resources are being utilized.




The Carrying Capacity of Land | ^
“That may be all well and nice,” one reply may go, “but there is still an important commodity of which you cannot produce any more units, no matter how cost-effective are. There really is a fixed quantity of land. Its carrying capacity —the number of people who can safely fit on it and live — is finite.” Yet market economics have indeed increased the carrying capacity of that. This is in two respects. First, technological improvements have allowed for a larger number of people to live peaceably on the same square acreage as before. Secondly, the same plot of land can grow greater quantities of food than it has in centuries past.

Let us first begin with how technological innovation has enabled a greater quantity of people to live and work on the same the square footage of land. Throughout the nineteenth century, the U.S. population grew for two reasons. First was the influx of immigrants from Southern and Eastern Europe, masses seeking new opportunity. Second was that the improvements in living standards from industrialization were already beginning to reduce the death rate. Yet this led not to crowding alone but also an increase in the real price of housing. Rents would go up. Entrepreneurs observed that profit was to be made by finding a novel solution to this. It would come in the form of a change in housing itself.

For much of the past several thousand years, human beings had difficulty with high-rises. And that was with good reason. Most buildings were structures supported by their outer walls. The taller the structure was, the greater a burden the structure put on its base. The base had to be the widest section, much wider than the building’s top. Hence, most tall artifices, be they in Egypt or in Mesoamerica, had to be constructed in the shape of pyramids. The walls having to be wide reduced the space on the interior, and there was less interior space still near the top of the structure.

This was dealt with in the late nineteenth century. This was when, due to greater economic freedom than in centuries past, such figures as George Westinghouse and John D. Rockefeller, Sr., thrived. It was this environment that created opportunities for a pioneer in the designing of skyscrapers, William LeBaron Jenney.

One day upon looking at his wife’s bird cage and the bars on the outside, inspiration breathed new life into Jenney. Limitations were placed on a building’s height exactly because of how architects had traditionally relied on the outer walls supporting the structure. Instead, Jenney reasoned, the structure should be supported by a metal frame — a sort of skeleton — inside the inner walls. The construct, then, would not need to be pyramid-shaped; the highest story could be just as spacious as the lowest.

This greatly increased the carrying capacity of land. As noted by London’s Economic Development Office, “Accommodating the same number of people in a tall building of 50 stories as in a large building of five stories requires roughly one tenth of the land.”

Many great technologies enabled farmers to grow more food per acre of earth. From 1950 to 2001, corn yields per acre in the United States tripled




Improved Productivity Helps People on the Lower Income Distribution | ^
And the result of all the aforementioned entrepreneurial ingenuity has been improved living standards. Moreover, with the exception of one category of product we will discuss later, this has led a reduction in real prices over most consumer goods, especially food. Here we must emphasize the distinction between nominal prices and real prices. Nominal prices are the price of a product taken at face value. A candy bar priced at two cents in 1904 was 44 cents in 2009. The nominal price in the latter year was twenty-two times that of the former year. 

The main cause of inflation is the U.S. Treasury and U.S. Federal Reserve putting more and more monetary units in circulation. When the quantity of monetary units increases at a rate that exceeds that rate at which the quantity of goods and services increases, that is more monetary units chasing after the same goods and services. Vendors have to raise the nominal prices of their goods; otherwise, there will be a shortage. This inflation hurts most the parties that are living on savings and fixed incomes, such as senior citizens collecting their retirement. That is why policymakers should listen to free-market advocates concerned about the Treasury and the Fed devaluing the currency. But that is another essay for another time.

Germane to this particular essay, because inflation obscures actual changes in prices, we need another metric by which to judge the extent to which prices have changed over the decades. Many economists rely on something called the “consumer price index” in order to measure inflation. With it, they calculate how much economic value a U.S. dollar from today could have purchased in past years, be they 1930, 1940, or 1950, and vice versa. What a single nominal U.S. dollar could purchase in 1900, for example, was the equivalent of what a nominal $31.10 could purchase in 2020. A price that is calculated to account for inflation is known as “real price.”

Economist W. Michael Cox, formerly of the Federal Reserve Bank of Dallas, has another approach. He asks his fellow citizens to consider the average amount of time someone had to spend at work in order to purchase a particular good.

By that standard, the trend has been for important goods to get cheaper and cheaper. For someone in the year 1930 to afford 100 miles’ worth of air travel, that person would have to do the equivalent of twelve hours and 46 minutes’ worth of work. By 1990, one could purchase that same 100 miles of air travel by working one hour and two minutes. In 1900, affording 100 kilowatt hours of electricity would entail working for 107 hours and 17 minutes. By 1990, that quantity could be earned by spending 43 minutes at work.
The same trend is seen with food. In 1940, a person had to spend one hundred hours on the job to be able to purchase a three-pound chicken. By 1990, that chicken could be purchased after spending fewer than twenty minutes. The downward trend in prices here cannot be attributed properly to federal legislation such as the Fair Labor Standards Act of 1938. The price of chicken was already falling. Between 1900 and 1930, the number of hours one had to labor to obtain this three-pound chicken fell from 160 to 110.



Citing a 2004 study by Erik Rauch at MIT, utilizing U.S. Bureau of Labor Statistics data from 1947 to 2000, Silicon Valley tech writer Andy Kessler observes that by the year 2000, someone would only need to work eleven hours a week to attain the equivalent value of what someone earned from a full forty-hour work week in 1950. To put it into perspective, Kessler writes that “we could have knocked 30 minutes off the average work week every year since 1950” and by the year 2000, “still maintained our 1950 standard of living.”

And, indeed, even as lithium is employed more efficiently in machines, its real price keeps falling. Between 2010 and 2019, its price per kilowatt hour in 2019 U.S. dollars descended from $1,183 to $156. In nine years, that was a more-than-fivefold decrease.

For many consumer goods today, a single hour of work will buy for someone in the First World a larger quantity of theese consumer goods than that same hour of work would have fetched for any previous generation. That is a net gain in wealth for everyone in the First World.
 
In the United States, a household falling under a certain income threshold puts it under the official federal poverty line. Whether the household is in poverty is calculated by the U.S. Department of Health and Human Services according to the household’s income and the number of people living in it. As of this writing, a family of four is under the poverty line if it brings in less than $26,500 annually. Even many households under this poverty line provide evidence of how living standards improve to the extent that people are free. In 1950, fewer than 80 percent of all U.S. households possessed a refrigerator. By 1997, a refrigerator was in 90 percent of U.S. households falling under the federal poverty line.


Goods That Have Not Decreased in Real Price | ^
The general trend for units of consumer goods is not only for smaller quantities of natural resources to be inputted into their creation but also for them to decrease both in real cost for the manufacturers and real price for consumers. All these reductions are the consequence of improved industrial efficiency. Yet one may notice that the general price decreases do not apply to most of the pharmaceuticals and medical devices I mentioned in Part One of this essay. Genentech’s human insulin reduced costs for producers but it did not substantially shrink in real price for diabetic patients. Nor were there big price reductions in cancer drugs after the release of those from Patrick Soon-Shiong and Axel Ullrich. That is because, sadly, there is one large, general category of product to which the reductions in real price have not applied. This is actually not a failing of laissez-faire free market principles, however.

The products that have not decreased, but which instead have often increased, in real price include health care, pharmaceuticals, medical devices, higher education, and residential homes. What these goods and services have in common is how much of a financial commitment they all are. And they have something else in common. It is that the federal government has instituted measures to help people obtain cash or credit to procure these goods and services. Medicare and Medicaid assist in paying for health care, prescription drugs, and medical devices. Federal loans assist in obtaining higher education and housing — two goods so great in expense that they are paid for in installments.

Click on image to see website it is from.

These are taxpayer subsidies. Even if the borrower pays back the federal loan’s principal plus interest, there remains, on a net balance, a taxpayer-funded payment to the borrower. The reason for that is that the interest rate the federal government charges is always less than the interest rate that would have been charged by a privately owned lending institution. The difference between the government’s and the private lenders’ interest rates is absorbed by taxpayers.

What happens is as follows. First, a particular good in this category is considered too costly. The government then provides taxpayer subsidies to assist in purchasing these goods. However, this raises demand, and the providers of these goods respond to this rise in demand by raising prices. Paying for real estate grows more daunting, as it does with university tuition. As these prices ascend, activists and the general public clamor for larger subsidies to cover these new higher prices. Taxpayer subsidies purported to make a particular good more affordable therefore ultimately make that good more expensive.

Although other writers such as economist Richard Vedder have described this phenomenon before he did, Robert W. Tracinski gives an apt name for this — the Paradox of Subsidies.

Laissez faire is not to be blamed for this predicament. Nor does it follow that these goods and services would not decrease in real price if none of the taxpayer subsidies existed. Cosmetic surgery and LASIK eye surgery, for example, are not covered by health insurance or taxpayer subsidies. Exactly for that reason, such procedures have plunged in real price over the past 15 years.

Recall that throughout the 1950s, Percy Julian was able to reduce the price of progesterone tenfold. By contrast, the legislation in 2006 to ensure that Medicare pay for prescription drugs has only driven up the real price of medication.

Food purchases are also subsidized in the form of food stamps, now called the supplemental nutritional assistance program (SNAP). But all of those who are concerned about food prices should be thankful that these subsidies go to a minority rather than the majority of the population. If the vast majority of Americans paid for their sustenance with SNAP, the real prices of food would be steadily increasing as well.

Laissez faire not being the culprit for the rising real price of taxpayer-subsidized goods, we see that in areas where markets are freer, the freedom of enterprise to improve efficiency has shrunk the quantity of natural-resource inputs used and has lowered real prices for goods and services.




The Poor Get Richer | ^
Yet most of the world’s human population persists in being poorer than it should be. As discussed earlier, there are still many casualties from people breathing — as they try to keep warm — the fumes rising from their fireplaces. The main reason for the holdup in development is that most countries have kleptocratic governments. People practice commerce but their governments usually refrain from protecting them from theft. Often on a whim, the State itself will seize the people’s meager belongings. But as to the extent that they have experienced any liberalization, such as the country becoming more open to international trade and direct investment, the perks of liberalization have conferred improvements in living standards upon the developing world’s residents.

Consequently, average living standards have climbed in both the rich countries and the developing ones over the past half-century. It is here often interjected that the statistical mean, the average among all the numerical figures, is not always the statistical mode —the numerical figure that, among all the cases, recurs most often. If the mean global annual income shot up, what if all the gains went to the wealthiest one percent of the population? Maybe inflation-adjusted incomes for everyone else has remained the same or fallen? The economists David Dollar and Aart Kraay looked into this. They found, “When average income rises, the average incomes of the poorest fifth of society rise proportionately.” A trio of academic economists led by John Luke Gallup had a corroboratory result. They discerned “a strong relationship between overall income growth and real growth of the income of the poor.”

We can gain insight into these changes by observing what the United Nations defines as life-threatening absolute poverty. Someone falls under that threshold if that person makes less than $1.90 per day in inflation-adjusted 2019 U.S. dollars. This should not be confused with the U.S. federal government’s criterion for falling under the country’s official poverty line. Someone can be under the U.S. poverty line but still be out of absolute poverty by the U.N.’s standard.

Overall, the rate of life-threatening absolute poverty has been slashed, even in the developing countries. Between 1981 and 2008, the share of the global human population in life-threatening poverty dropped from 52 percent to 22 percent. That is a figure sliced by more than half.


And China’s ascension to wealth is not sufficient to explain this decline. Professor Max Roser of Our World in Data scrutinized what the results were when China was excluded. In 1981, 29 percent of the non-Chinese human population was in absolute poverty, whereas in 2013 the figure was 12 percent. For such reasons, Georgetown University economics professor Steven Radelet finds it necessary to emphasize that the “improvements” in living standards among the developing countries “go well beyond China.”

Many find it tempting to attribute this poverty reduction to taxpayer-funded foreign aid and to charitable NGOs. They have played a role, but as U2 front man Bono notes, something else has more to do with it. “Commerce — entrepreneurial capitalism,” he told an auditorium of Georgetown University students, “takes more people out of poverty than aid.” The data corroborate Bono’s assessment. Columbia University’s Howard Steven Friedman inquired into how much, between the years 2000 and 2013, the taxpayer-funded U.N. Millennium Development Goals (MDG) had to do with the developing countries’ gains in living standards. It turns out the MDG had very little to do with the improvements; it was mostly for-profit commerce and private charity. In the few cases where some taxpayer-funded government project helped, such as with the construction of municipal roads, that came from municipal government and municipal taxation, not taxpayer-funded aid from the rich countries.

The World Bank does not attribute trade as the prime reason for the poverty reduction, but the trade does contribute to what the World Bank determines is the prime reason. As the World Bank explains, “the creation of millions of new, more productive jobs, mostly in Asia, but also in other parts of the developing world, has been the main driving force” behind the fact that “poverty has declined in the developing countries.” After all, “the private sector is the main engine of job creation and the source of almost 9 of every 10 jobs in the world.”

Among those jobs are those that capitalism’s detractors have reviled as exploitation. These would be initially low-paying jobs in factories established through foreign direct investment, factories often derided as “sweatshops.” From the 1950s onward, Asians opted for these sweatshops in the city because they paid two to three times as much as those in the village or country. Contrary to modern assumptions, in countries that are more politically liberalized we find that the trend is not for the majority of the workforce to be stuck in low-paying drudgery for decades on end. Reason magazine has profiled a factory in Taiwan that, during the 1970s, manufactured Barbie dolls. The workers in such factories saved their money and sent their children to schools to hone other skills. That is how countries such as Japan and Taiwan arose from destitution to First-World affluence. A similar phenomenon took off in India in the early 1990s with its deregulation of information technology.

The World Bank’s 2013 findings on poverty reduction corroborate Ayn Rand’s observations from over three decades earlier. She already noted that insofar as it has been implemented, capitalism has “raised the standard of living of its poorest citizens to heights no collectivist system has ever begun to equal, and no tribal gang can conceive of.” For such reasons, Rand related elsewhere, “If capitalism had never existed, any honest humanitarian should have been struggling to invent it.”

Although she did not know about him as she wrote those words, Ayn Rand seems to be anticipating the epiphany that Bono has had about global economics. Taking his Catholicism seriously, Bono had always concerned himself with the plight of the poor. When he first rose to fame in the 1990s and exercised his celebrity status to bring attention to this plight, he originally went by the conventional interpretation of capitalism being evil. One day at a conference, he met African development economist George Benjamin N. Ayittey, who implored him to consider it from another angle. As Bono observed over the decades which antipoverty measures worked and which did not, it was exactly his concern for the well-being of the poor that his impressions about capitalism had changed. He imparted to Rolling Stone magazine, “If you told me twenty years ago that commerce took more people out of poverty than aid and development, I’d have scoffed.” He is not scoffing anymore. Instead, he laughs in his speech to the Georgetown students, “ ‘Rock star preaches capitalism.’ Wow! Sometimes I hear myself, and I just can’t believe it!”

We often hear that capitalism must be fought by antipoverty programs. Yet capitalism is the antipoverty program.

That cliché that Percy Bysshe Shelley popularized about the rich causing the poor to become poorer is economically illiterate. To the extent that people are free to enterprise, the rich get richer and the poor get richer.

From the relative liberalization in the nineteenth century, and as a result of its consequent Industrial Revolution, the average lifespan in the United Kingdom, Western Europe, and North America ascended from 27 years in 1800 to 77 years by 1988. Starting in the late twentieth century, the developing countries began to experience comparable effects to the extent that they have been exposed to the gains of liberalization.

Georgetown University economist Steven Radelet points out that between 1980 and 2015, “the rate of child death has declined in every single developing country in the world where data are available. There are no exceptions” (emphasis Radelet’s).

And, as Max Roser notes at Our World in Data, the boost in average lifespan is due not only to reductions in the infant mortality rate. Thus, contrary to the final chapter of the book ScienceHeroes.Com was created to advertise, there is no conflict between “Our Health” and “Our Wealth.” Each of those reinforces the other.

Throughout Part One, we learned of how illustrious entrepreneurs organized the creation and distribution of specific products that saved lives. Here, in Part Two, we begin to see how all those efforts add up.




What Capitalism Can Do for the Climate | ^
For the purpose of saving space, I have relocated this section of the essay to this separate blog post. The bottom of that blog post has a link to return to this one.




Capitalism Vs. Hunter-Gatherer Life Vs. Socialism | ^
No, insist detractors. In lieu of just developing new technologies to continue with man’s consumption of resources, they declare, everyone should just learn to live on less —especially the vendors of the world. Anti-capitalists see vendors such as Wilson Greatbatch not as wizards who enrich others through their inventiveness as much as they see them as predators who extract money from customers.

These anti-capitalists remember a time in their childhoods when their parents or guardians provided the amenities. As adults, these anti-capitalists yearn for the presence of some still-higher-ranking parental figure who can bail out adults in their desperate hours. They remember stories of how human beings once had the abundance of the Garden of Eden, only to lose it. Upon being banished from paradise, human beings were thereafter doomed to mortality and the need to struggle for sustenance. No matter the net increases in global economic value provided by the George Westinghouses and Wilson Greatbatches of the world, they will never measure up to the standard set by Eden.
Westinghouse and other vendors, then, are not geniuses who have raised us beyond the living standards of cavemen. Instead, in expecting payment for units of their inventions, the Westinghouses and Greatbatches are holding these units for ransom. The customers’ need is the basis of what they deserve. Once the ransom is paid off, these vendors release to their customers the units of value that were rightfully owed to the customers from the outset.

But the reality is reverse. The abundance of the Garden of Eden was never the default. Rather, the default has always been life-threatening poverty. Industrialization and capitalism “did not create poverty,” Ayn Rand elucidates. They “inherited it.” More than that, as we have seen, it is industrialization and capitalism that have done the most to alleviate this penury.

Socialism has over a century of promising that Edenic plenty, of all customers getting everything they need. And socialism has failed for that more-than-a-century, performing worse than whatever amount of capitalism has existed. Yet in its constant false promises, socialism continues to be hailed as more desirable than capitalism.

Such considerations are denied by various opponents of capitalism. Propagandist Michael Perelman huffs about private ownership of agricultural land replacing the practice of shepherds grazing their flocks on the medieval commons. Others go back even farther in time. They cite the living conditions of hunter-gatherers as far better. Many of the lifesaving innovations profiled in Part One were a remedy to dangers imposed by previously established technologies. George Westinghouse’s air brake cut the number of railroad fatalities, but there would never have been a need for this air brake if locomotives were never invented. Electric heating that Westinghouse helped make possible has saved people from having to damage their lungs in the employment of fireplaces. But people would not have suffered from this indoor air pollution if no houses were built. After all, for most of the species’s history, hunter-gatherers have managed to live without skyscrapers, houses, or cabins.

Yes, it is quite fashionable for people, even many self-proclaimed admirers of Ayn Rand’s, to idealize the hunter-gatherer mode of existence. They say that such an arrangement was more pleasant in that the average number of hours of work a hunter-gatherer has to perform to obtain daily meals is a mere four hours. The major source of that figure is anthropologist Richard B. Lee. Arguing along these lines, anthropologist Marshall Sahlins judged that having so much leisure time made hunter-gatherers “the original affluent society.” And, continue the anti-capitalists, the figure about the average lifespan being low among hunter-gatherers is misleading. What mainly drives down the average life expectancy, goes the argument, is the high infant mortality rate. But, continues the argument, if someone lived to be two years old, there was as a great chance of her living to be eighty years old.

There is much to unpack from that.

First, the figure about hunter-gatherers only needing to work an average four hours per day for food is the actual instance of a statistical mean being misleadingly presented as a statistical mode. The anti-capitalists’ citation of this figure brings to mind the false image that, every day, the hunter-gatherer works no more than four hours, and then spends the rest of the day on quality time with family and recreation.

In reality, there is much irregularity in the number of hours per week on obtaining food. Typically, the men in such a band will spend several days attempting to hunt for game or to forage. Often, they can come back with nothing. They next spend the next several days on resting. This is the cycle on repeat.

Further, when anthropologist Richard B. Lee calculated that it took an average four hours per day to obtain their nourishment, Lee mentioned a fact that is seldom acknowledged by people who cite his four-hour figure. It was that, in calculating the average number of hours of “work,” Lee did not count the number of hours that these hunter-gatherers then have to spend on what Lee calls “housework.” Such housework includes the processing of the food that has already been retrieved. The same !Kung San bands that Richard B. Lee studied happened to spend eight hours a week on cracking the mogongo nuts they gathered, four to seven hours per week on assembling or repairing their tools, and fifteen to twenty-two hours per week on butchering and cooking meat and on collecting firewood. As food historian Rachel Laudan summarizes, “each adult spent between 27 and 37 hours a week on food processing and ancillary activities: fuel, water and tools. . . . Thus the total work week for the bushmen on the lowest of estimates turns out to be between 6 and 7 eight-hour days (not counting child care).”

Now we can turn our attention to life expectancy among hunter-gatherers. There is something perverse about people citing, as a counterpoint to the idea that hunter-gatherer subsistence is harsher than modernity, the argument that it is only because of a very large infant mortality rate among them that the average life expectancy of hunter-gatherers is driven down so low. After all, as stated previously, the infant mortality rate among hunter-gatherers is usually one in four. People who make this argument should bother to listen to themselves. That the infant mortality rate would be large enough to do that should be acknowledged, from the outset, as a major indication of how much more perilous the conditions of hunter-gatherer life are. More relevantly, that it has been able to reduce the infant mortality rate from 25 percent to less than one percent is a credit to industrialization and modernization. This is the same industrialization and modernization being belittled.

Moreover, it is not accurate that as long as someone survived being age two, it made it likely for that person to reach age eighty. In mass graves of hunter-gatherers, it is unusual for archaeologists to find anyone who lived to eighty. Even into the days of ancient Rome, some people were lucky enough to reach their seventies, but the percentage of the population that reached such an age was smaller back then than it is today.

Max Roser of Our World in Data demonstrates that, since the year 1700, the rise in life expectancy goes far beyond the salutary reduction in the infant mortality rate.

Overall, the mortality rate is lower for people in modern, liberal, republican, commercial societies than in hunter-gatherer bands, and for every age bracket.

Examining females in the Hiwi band who reach the age of fifteen, only a quarter will live to 70. By contrast, with fifteen-year-olds in a modern industrial society, three quarters can expect to be around for their seventieth birthday.

In members of the Arikara clan found in mass burial sites, the mortality rate for those aged 20 to 40 was 15.3 percent. In American citizens today in that same age range, we find a mortality rate of 3.7 percent.

Ah, counter the opponents of commercialism, escaping the evils of capitalism does not require that we go so far as abandon modern technology in favor of a return to being hunter-gatherers. Nay, they say. We can adopt the political-economic collectivism that is common to hunter-gatherer bands while maintaining the conveniences brought about through industrialization. This shall be accomplished, they offer, through old-fashioned socialism of one sort or another.

Ever since the rise in popularity of Bernie Sanders and Alexandria Ocasio-Cortez, it has, once again, become trendy for Americans to insist that socialism could provide this wealth to a much greater degree than capitalism. The history of the twentieth century does not bear out such an assertion. To the extent that capitalism’s detractors think of socialism as the rich being taxed to pay for social service programs for the poor and middle class, that is actually a welfare state or regulatory-entitlement state. There are great weaknesses to this alternative, but that is another essay for another time.

Let us compare “socialism” as it has been more traditionally defined from the late nineteenth century to the mid-twentieth century. “Socialism” here refers to the public —usually with the government acting as its representative — having collective ownership over heavy industry, such as steel production and automobile manufacture. When a national government has its own agency attempt steel production or auto-making, that agency is known as a State-owned enterprise (SOE). Rather than the selfishness imputed to competing firms that seek profit, the State-owned enterprise is nonprofit and supposedly acts for the good of all.

If we want to look at such socialism being practiced in countries that remained democracies, we can look to Sweden, the United Kingdom, and France from the end of World War II to the late 1970s, the latter period being when the government began converting the SOEs into privately owned, for-profit firms.

Ove Granstrand and Sverker Alänge partook in a study of their native Sweden, examining the origins of the country’s hundred “most economically important innovations” to emerge in the duration of 1945 to 1980. Eighty percent of the innovations originated from major private, for-profit corporations. Twenty percent arrived from then-small startup firms. By contrast, innovation from State-owned enterprises was “marginal,” . . . meaning zero.

Someone who had to confront this reality was Nelson Mandela. For decades during his campaign against apartheid, Mandela proudly called himself a radical socialist itching to nationalize the means of production and turn private companies into State-owned enterprises. Then as South Africa’s leader, throughout the 1990s — the same decade of Bono’s transformation — Mandela met with dignitaries from the former Soviet Union and post-Maoist China. They extolled the significance of privatization. Speaking of those meetings, he told his biographer Anthony Sampson, “I came home to say: ‘Chaps, we have to choose. We either keep nationalization and get no investment, or we modify our own attitude and get investment.’ ”




Capitalism Vs. Taxpayer Funding for Basic Research and R-and-D | ^
Yet it is often stated that even if outright socialization of heavy industry is a failure, governmental intrusions on market activity are still warranted in terms of allocating taxpayer outlays for specific R-and-D efforts. The assumption here is that politicians and government officials are a better judge than are private investors in determining which R-and-D projects will produce results beneficial to everyone. After all, Patrick Soon-Shiong’s nab-paclitaxel merely improved upon a different drug whose development was funded federally by the National Cancer Institute. Likewise, this NCI provided grants to the same Dennis Slamon who had to pester Genentech Corporation to get behind trastuzumab. An article from Kaiser Permanente states that both the BioNTech and Moderna COVID vaccines rely on the federally funded research of Dr. Barney Graham.

I once came across someone on Facebook who insisted to me that all great new inventions came from “government research labs.”

It is a cliché for taxpayer funding’s apologists to comb through the history of the sequence of events that led to the development and refinement of a particular technology, such as smartphones and hydraulic fracturing. Upon finding any instance in this sequence of events where someone in R-and-D received any taxpayer funding, these apologists declare triumphantly that this useful technology would exist in no form if not for the taxpayer funding.

That is a red herring. The issue is not whether anyone received taxpayer funding at any step of the process through which a technology has evolved. The issue is whether value-adding technologies can emerge in the absence of taxpayer funding. Indeed, they can. The primary distinction between the governmental sector and the nongovernmental sector has to do with violence and peace, respectively. Everything outside of direct government involvement — such as for-profit businesses, not-for-profit organizations, and domestic life — is supposed to be nonviolent. Insofar as private parties rely on the threat of violence to assert their will, they are in violation of the law. Then the State is correct to intervene against these parties initiating the use of force.

By contrast, the government is doing the very job for which it was created when it threatens to send armed men against parties that obstinately break its rules. That principle applies even when the initial penalty for disobeying a law is a tiny civil fine. Someone who ceaselessly refuses to pay such fines will eventually be found to be “In Criminal Contempt of Court,” and armed men will be dispatched on this lawbreaker. The government sector and the nongovernment sector are, respectively, the violent sector and the peaceful sector.

Anything that people can do in the absence of threatening violence, people can do in the absence of direct government involvement. To the extent that interested parties can obtaining resources for their research without threatening violence on those who refrain from providing them resources, they can do it without taxpayer funding.

The above is not mere theory. The data themselves undermine the narrative that taxpayer funding is needed, as is sometimes acknowledged by government agencies themselves. First in 1991 and then in 1997, University of Pennsylvania economist Edwin Mansfield inquired over the matter. Between 1986 and 1994, taxpayer-funded research accounted for a mere 13 percent of the new drugs released by U.S. companies. Conversely, 87 percent of the new pharmaceuticals were developed in-house by the companies’ own private capital appropriations. Likewise, in that same duration, taxpayer-funded research accounted for 14 percent of the information-technology products developed. Meanwhile, again, 86 percent of the new IT products were developed in-house, through private financing.

More recently, one can find even government studies that corroborate this.

On the U.S. Bureau of Labor Statistics’ behalf in 2007, Leo Sveikauskas reviewed the literature. He discovered, “The overall rate of return to R-and-D is very large, perhaps 25 percent as a private return and a total of 65 percent for social returns. However, these returns apply only to privately financed R-and-D in industry. Returns to many forms of publicly financed R-and-D are near zero.”

In 2003, Stefan Scarlett and associates reported for the Organization for Economic Cooperation and Development, “The results also point to a market positive effect for business-sector R-and-D, while the analysis could find no clear-cut relationship between public R-and-D activities and growth, at least in the short term.” And the OECD report went even farther, admitting that taxpayer-funded R-and-D has a “negative” correlation with economic growth and innovation. Hence, the report admits, such results “suggest publicly-performed R-and-D” wastes “resources that could be alternatively used by the private sector” more productively, “including private R-and-D.”

Someone who has something to say on this is lifesaving laser inventor Gordon Gould. He has worked on both top secret Pentagon operations and for private companies. In his mind, “Big projects can get done in government research labs, but you don’t see much inventiveness.”

As stressed by he and Wilson Greatbatch, the major source of lifesavings innovation is freethinking individuals who are able to pursue their interests through free enterprise.

Recall that from the Paleolithic Period to the present, a fifteen-year-old’s chances of living to age seventy increased from one in four to three in four. That is due to technological innovation. And the technological innovation is attributable less to government-mandated “investment” than market economics itself.



CONCLUSION | ^

Accounting for everything, it is hardly doing justice to capitalism for Lindsay Ellis to say that corporations “make us stuff — not useful stuff, but stuff.” The “stuff” is more than useful. It includes pharmaceuticals, medical devices, and other goods that have lengthened lives and added to their quality and comfort.

Contrary to the assumptions of Alexandria Ocasio-Cortez and her counsel Dan Riffle, someone such as Patrick Soon-Shiong acquiring a billion dollars’ worth of monetary exchange value does not deprive the rest of the human population of a total billion dollars’ worth of resources. That entrepreneur’s billion is the consequence of that entrepreneur obtaining natural resources and, by exercising a technique to boost efficiency, changing those natural resources in such a manner that they now provide a greater benefit to human beings than they did in their previous state. The billionaire’s profit is equal to the new value that the billionaire’s efforts produced from the resources inputted, a net increase in the value of the resources employed.

Consider a gram of lithium. Starting in the middle of the nineteenth century, it was occasionally imbibed as a form of medication. For the most part, though, it was exotic. It would not have provided much value to the average person living in the year 1870 or even 1930. Once converted into a particular form, however, that same gram of lithium proved to be of much more practical and immediate value to someone in the year 2009. This is on account of electronics tycoons such as Craig McCaw, Philippe Kahn, and Steve Jobs having lithium power their mobile phones and of medical-device innovators such as Wilson Greatbatch exploiting it to enhance his pacemakers. That usefulness — that value — added to the lithium is economic value that such entrepreneurs created, and for which they are paid in kind. Absent of “the creative power of man’s intelligence,” Ayn Rand reminds us, “raw materials remain just so many useless raw materials.”

Hence, we understand the fallacy of Alexandria Ocasio-Cortez proclaiming, “I do think a system that allows billionaires to exist — when there are parts of Alabama where people are still getting ringworm because they don’t have access to public health — is wrong.” There is no merit to the insinuation that someone having a billion dollars contributes to those Alabamans having ringworm. The best hope for those Alabamans is that an ambitious scientist-entrepreneur will brainstorm a procedure whereby she can profit from providing those Alabamans better medical treatment than what they have received previously.

` When it comes to what he said about twenty-three types of deodorant proving how Americans’ priorities are misplaced, it is projection on Bernie Sanders’s part. There is no inherent inverse relationship between children being fed and their parents being able to choose different types of deodorant. Through the smart employment of resources, there can be more meals for kids even as a variety of deodorants and snazzy sneakers go to market.

If someone acquires a billion dollars through the sale of goods or services, it is because his planning and organizing skills had created, for the world, a net increase in economic value of such magnitude that his customers willingly paid him a total one billion dollars for it. And those customers made such deals because what that entrepreneur provided them was of greater value to them than the money they paid him. The principle remains the same if an entrepreneur becomes a billionaire on account of a rise in the price of corporate shares he owns. In that case, the entrepreneur earns those would-be investors’ confidence that his company will profit its owners by providing great value to customers in the future. Anticipating that the entrepreneur will continue to exercise such competence, demand for ownership in the entrepreneur’s company increases among investors. The more eager the investors are to gain a piece of the action, the greater the demand is for shares in the entrepreneur’s company. Capitalism saves lives and is win-win.

Yet a reader who has been a longtime fan of Ayn Rand’s might notice that she was not fond of an expression like “capitalism saves lives.” That might initially seem strange, considering her status as capitalism’s biggest champion. But there is a special reason for this. The phrase “save a life” is usually spoken in a context where the default is someone going about her life only for some extenral threat to come at her suddenly, which is thankfully removed just as soon.

Capitalism, as Ayn Rand understood the term, is a social system where a liberal republican government allows for people to do anything that is peaceful. Trade and commerce in human history go back at least as far as the Neolithic Period. But even as this commerce was carried out, authority figures could arbitrarily overrule people’s trades and confiscate the fruit of their efforts. It was not until the Enlightenment and the Industrial Revolution that philosophers and statesmen began to enshrine, formally and eloquently, the individual’s right to live and prosper. There would always be some criminals who would try to prey on others, but they would be an aberration. In Ayn Rand’s estimate, then, capitalism did not keep having to “rescue” its citizens. Rather, as far as the threat of violence is concerned, capitalism allows for people to go about their lives without their having to be rescued or saved in the first place.

Definitely, modern industrial capitalism avails to people more opportunities than in centuries past, often because of the new resources whose creation industrial capitalism has facilitated. To try to make a career as a musician in antiquity or during the high Middle Ages, someone would usually have to be born into a family of musicians just to be able to access a high-quality musical instrument. Someone able to master such an instrument would usually then be confined to performing directly before a baron or a politically-connected family.

By contrast, as a consequence of the bounty that market-based industrialization has afforded, someone trying to be a musician today can access many more resources. A middle-class person can record her music and put it on the internet. If she can play multiple instruments, such as a bass guitar and the drums, she can record herself playing each instrument in a separate session, and then put all the sessions together as if she were an entire band playing all the instruments simultaneously. Achieving superstardom is still not easy. The process is more competitive than ever, but it is not for a lack of resources for someone of relatively modest means. Inasmuch as someone wants to pursue her own creative passions and dreams, no social system enables that more than constitutional, liberal republican capitalism. Capitalism enables you to live — not just in terms of survival, but to live in fulfillment, as in make an attempt at the sort of life you want for yourself.

The welfare state and socialism have promised to endow their citizens with greater material security than capitalism ever could; they promise greater access to healthcare and housing. Pursuing one’s artistic passions often interfere with the ability to work a more conventional job to pay for the amenities. Hence, our would-be musician may fantasize about receiving taxpayer funding that can secure her financially so that she has more time for her craft. But every resource a welfare state or socialist government hands out must be taken forcibly from someone. The contradiction inherent to socialism and the welfare state is that their promises of security to someone are enforced by the threat of police violence against others. Rather than say that capitalism saves lives, Ayn Rand judged that capitalism — insofar as it is implemented — is the only social system that enables someone to live a completely human life at all.

Hence, the closest Ayn Rand has come to saying that capitalism saves lives was in her observation that if capitalism itself needed to be “saved” — saved from being replaced by something else — or else the result would be peril to all. In her words,
We must define, understand and accept individualism as a moral law, and Capitalism as its practical and proper expression. If we don’t — capitalism cannot be saved. If it is not saved — we’re finished, all of us, America and the world, every man, woman and child in it. Then nothing will be left but the cave and the club [emphasis hers].
Still, perhaps the principle can be phrased in terms that most people might find familiar. Capitalism does rescue people from the high mortality rates found in hunter-gatherer bands and other pre-industrial societies. If Ayn Rand had to write the phrase at all, it would probably be to state that capitalism saves your life every day.

Billionaires and capitalism do provide us “stuff,” yes, but there is a much grander result than that. To the extent that the relative freedom of a liberal republic has been of benefit to you, billionaires and capitalism have saved both your life and mine.